- Generating Monoclonal Antibodies - Cold Spring Harbor
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- GRG 301C Unique #s 37680 to 37735 Spring 2014 Prof.
- Sierra College
Generating Monoclonal Antibodies - Cold Spring Harbor
Here we show that the full-length form of E12 inhibits Myo D function.
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The first 83 amino acids of the inhibitory N terminus of ITF-2B show hh sequence homology to the N terminus of full-length E12/E47.
GRG 301C Unique #s 37680 to 37735 Spring 2014 Prof.
Previous studies that showed activation of Myo D by E12 used an artificially N-terminally truncated form.
A conserved α-helix motif, capable of interacting with the transcriptional machinery, was not essential for inhibition.
Chem 2b lab manual spring 2014:
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